July - December 2007
Volume 4 | Issue 2

This journal has been online since Saturday, April 05, 2013

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  LIVER FUNCTION TESTS PROFILE OF SICKLE CELL ANAEMIA PATIENTS IN STEADY STATE OF HEALTH: ZARIA EXPERIENCE

AKUYAM SA* BAMIDELE AS* AMINU SM** ALIYU IS* MUKTAR HM**

Correspondence to: Dr. S. A. Akuyam Department of Chemical Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Background: Several reports across the world suggest that liver and biliary tract dysfunctions are common complications of sickle cell anaemia (SCA). However, there is paucity of data on the pattern of liver function tests profile in SCA patients in Zaria. Most of the reported studies were carried out elsewhere. Objective: The overall objective of this study was therefore to evaluate the liver function status in patients with SCA in Zaria, northern Nigeria with a view to recommend or otherwise the inclusion of liver function tests in the routine investigation of SCA in Nigerian hospitals. Subjects and methods: The study was conducted in the Departments of Chemical Pathology and Haematology of Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, northern Nigeria. Serum levels of total bilirubin (TB), alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total protein (TP), albumin (ALB) and AST/ALT (De Ritis) ratio were determined in sixty (60) each of SCA patients and age- and sex-matched control individuals. These consisted of thirty (30) each of male and female patients and controls, respectively. The mean age of these patients was 21 years (ranged 13-40 years). Both the patients and controls were partitioned according to age groups, as groups I (13-20 years), II (21-30 years) and III (31-40 years) with thirty three (33), fifteen (15) and twelve (12) subjects, respectively. The data obtained were analysed using Microsoft Office Excel 2003. Two-tailed student's t- test for matched samples and one way analysis of variance (ANOVA) statistical methods were employed for the analyses. A p-value of equal to or less than 0.05 (p = 0.05) was considered as statistically significant. Results: The results of serum TB, ALT, AST, ALP, TP, ALB and AST/ALT ratio in SCA patients were 24.33±0.21 μmol/L, 47.17±1.51, 27.85±0.63, 145.05±6.45 IU/L, 75.35±0.97, 43.40±0.98 g/L and 0.7±0.06 respectively, while those in controls were respectively 16.09±0.79 μmol/L, 27.78±1.48, 15.78±0.90, 72.32±3.57 IU/L, 72.58±0.87, 50.48±2.26 g/L and 0.6±0.03. These results show that the levels of serum TB, ALT, AST and ALP were significantly higher in patients than in controls (p < 0.001), while serum ALB concentrations were significantly lower (p < 0.002) in patients than in control individuals. The results of serum TP and AST/ALT ratio in patients and controls were not statistically different (p>0.05). These results therefore, demonstrate that LFTs are mildly deranged in SCA patients. There were no gender variations in LFTs profile in both patients and controls. Serum TB and ALP in patients decrease significantly with advancing age, while serum ALT, AST, TP, ALB and AST/ALT ratio levels at different age groups were statistically similar. All the components of LFTs at different age groups in controls were statistically similar. Conclusion: It can be concluded from the findings of this study that there is a minor derangement in LFTs profile in SCA patients and that the extent of the abnormalities decreases with advancing age. This therefore, suggests that liver functions are impaired in SCA patients, most especially below twenty years of age. Therefore, it can be recommended from this study that routine evaluation of liver function status be considered in the management of SCA patients in Nigerian hospitals. This could assist in early detection of liver dysfunction and hence reduce morbidity and mortality from SCA in Nigeria.

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  KNOWLEDGE AND USE OF COMBINATION THERAPY FOR TREATMENT OF MALARIA AMONGST PATENT MEDICINE VENDORS (PMVS) IN KANO STATE

LAWAN UM* ABUBAKAR IS* GREMA BA*** NASIR NA**
Correspondence to: Dr Muhammad Lawan Umar Department of Community Medicine, Bayero University Kano, Kano State. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Background: Malaria is a leading cause of morbidity and mortality in the tropics. Objectives:To determine the knowledge of Malaria and combination therapy for its treatment among PMVs; and to investigate the use of combination therapy for treatment of Malaria, using a structured questionnaire. Methods: A cross sectional descriptive study was conducted among 162 randomly selected Patent Medicine Vendors (PMVs) Results: The results show that majority of the subjects knew about malaria but, only 31.5% of them have heard of combination therapy for treatment of malaria. The current recommended combinations for effective malaria treatment are not known to most of them. Only 14.2% of the PMVs had good knowledge of malaria and combination therapy for treatment of malaria. Up to 72.5% of those who were aware of the combination therapy have used one or more of the drugs on their patients. However, 64.9% of them used the drugs irrationally. Sulphadoxinepyramethamine and artesunate combination or amodiaquine and artemether were the common drugs prescribed. Conclusion: It was concluded that registration of PMVs should often the primary source of drugs used in the home, the potential role of this group as partners for effective malaria treatment and control had been recognized. The PMVs in Nigeria are therefore expected to be knowledgeable on malaria and combination therapy for its treatment. This study was therefore planned to assess the knowledge of PMVs on malaria and combination therapy for its treatment; and to investigate the use of combination therapy for treatment of malaria amongst PMVs in Kano State. Information from this research could be useful to policy makers.

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  CONTRACEPTIVE PRACTICES AND DETERMINANTS OF CURRENT CONTRACEPTIVE USE IN BORNO STATE, NIGERIA  

AD GEIDAM* BM AUDU* AA KULLIMA** MB KAWUWA**

Correspondence to: Dr AD GEIDAM Department of Obstetrics and Gynaecology University of Maiduguri Teaching Hospital PMB 1414, Maiduguri Borno State, Nigeria. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Background: Contraceptive use is poor among women in northern Nigeria, but it is agreed that regulating fertility goes along with socioeconomic development. It is therefore important to identify the determinants of contraceptive use in Borno state and utilise this for planning and advocacy. Method: The subjects were women of reproductive age living in urban as well as rural settings in Borno State, northeastern Nigeria. Questionnaires were administered enquiring about their socio-demographic characteristics and contraceptive practices. Logistic regression analysis was use to construct a model for
significant determinants of contraceptive use. Results: There were 532 respondents, with a mean age of 29.5+7.9 years and a mean parity of 3.4+3.0. Although 77.6% were educated, 68.4% were unemployed. One hundred and seventy five participants (32.9%) had 4 or more living children while 15.4% had no living child. In 15% of the cases, the husbands have no formal education. Eighty (33.8%) of the respondent were married into polygamous setting out of which 36 (20%) have 3 co-wives. The prevalence of current contraceptive use was 29.1% and majority of the clients (38.7%) used pills.
Previous contraceptives counselling and education were found to be the strongest determinants of contraceptives use. Conclusion: Making contraceptives counselling routine in all our gynaecological consultation and women empowerment through girl child education may help in the improvement of contraception utilisation. Further research is needed to address the men and co-wives issue with regard to family planning in our environment.

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  AN 8 YEAR CLINICAL REVIEW OF ANTEPARTUM HAEMORRHAGE AT THE UNIVERSITY OF MAIDUGURI TEACHING HOSPITAL, MAIDUGURI  

B. Bako, B. M. Audu, C. M. Chama, O. Kyari, A. Idrissa

Correspondence to: Dr.Babagana Bako Department of Obstetrics and Gynaecology University of Maiduguri Teaching Hospital P.M.B 1414, Maiduguri, Borno State. Nigeria E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Background: Antepartum haemorrhage is one of the obstetric emergencies associated with increased maternal and perinatal morbidity and mortality. Objective: To determine the incidence, types, predisposing factors, complications and outcome of antepartum haemorrhage. Methodology: A retrospective study of cases of antepartum haemorrhage over an 8 year period from January 1999 to December 2006 at the University of Maiduguri Teaching Hospital was carried out. Results: The incidence of antepartum haemorrhage was 1.6% (248/15512), while that of placenta praevia and placental abruption were 0.8% and 0.7% respectively. Typically, placenta praevia was detected early in the pregnancy as low lying placenta in 42(36.8%) of cases, while lower abdominal pain, uterine tenderness and woody hard uterus was found in 88(89.8%), 88(85.4%) and 68(69.4%) of cases of placental abruption respectively. The predisposing factors for antepartum haemorrhage were; increasing maternal age, multiparity, previous abortion, previous uterine instrumentation and uterine scar. Threatened abortion in the index pregnancy was associated with placenta praevia while maternal hypertension was associated with placental abruption. The first bleeding episode occurred intrapartum in 74(34.9%) of patients with APH and the majority of them (57 out of 74) had placental abruption. The commonest mode of delivery was caesarean section, which accounted for 135(63.7%) deliveries and 73.3% of these were patients with placenta praevia. Seventy seven women delivered vaginally and 80.5% of them were patients with placental abruption. Preterm labour and post partum haemorrhage were the most common maternal complications while prematurity and increased perinatal mortality were the most common fetal complications. The perinatal mortality was 85(40.1%). There was no maternal mortality from this series. Conclusion: Antepartum haemorrhage is an obstetric emergency associated with increased maternal and perinatal morbidity and mortality unless prompt resuscitative measures and appropriate treatment are offered. Early booking, appropriate referral of high risk patients and routine ultrasound scanning for placental localization are advocated for early diagnosis and optimum maternal and fetal outcomes..

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January - June 2009
Volume 6 | Issue 1

This journal has been online since Saturday, April 05, 2013

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  PATTERN OF PRESCRIPTION OF CO-TRIMOXAZOLE IN HIV-INFECTED CHILDREN FOR PCP PROPHYLAXIS IN MAIDUGURI, NIGERIA

GM ASHIR, AI RABASA, MG MUSTAPHA, F BASHIR, AB IBRAHIM

Correspondence to: DR GARBA MOHAMMED ASHIR Department of Paediatrics, University of Maiduguri Teaching Hospital, P M B 1414, Maiduguri, Nigeria E-mail This email address is being protected from spambots. You need JavaScript enabled to view it.

Background: Health education intervention is a combination of activities aimed at facilitating positive changes in behaviour and practices that may decrease risk of disease and thus reduce mortality and morbidity. Methods: In this study we have assessed the short term effectiveness of health education (clinical presentation) on the prescription of co-trimoxazole (CTX) as prophylaxis for Pneumocystis carinii pneumonia (PCP) in a cohort of HIVinfected children at the University of Maiduguri teaching hospital (UMTH). Results: The study showed a significant improvement in correct prescription of CTX for PCP prophylaxis after health education intervention. Conclusion: We concluded that health education intervention within a unit is appropriate, achievable and worthwhile..

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  PREVALENCE OF VULVOVAGINAL CANDIDIASIS AT A GYNAECOLOGICAL CLINIC IN KANO, NORTH-WEST NIGERIA

IBRAHIM SA* UGWA EA* AGU, OC** ONUORAH, CC***
Correspondence to: DR SA IBRAHIM, Department of Obstetrics and Gynaecology, Aminu Kano Teaching Hospital, Kano. Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Background: Vaginal discharge is a common complain in gynaecological and general practice. Objectives: To determine the prevalence of vulvovaginal candidiasis and how age, marital status and stages of reproduction affect this disease. Methods: High vaginal swab samples were collected from 859 women who presented with vaginal discharge at the gynaecological clinic. The data obtained was analysed using SPSS 14.0 statistical software. Absolute numbers and simple percentages were used to describe categorical variables. Similarly, quantitative variables were described using measures of central tendency and measures of dispersion as appropriate. Results: The prevalence of vaginal discharge in this review was 7%. Candida albicans infection constituted 84.5 % of cases presenting with vaginal discharge. Vulvovaginal candidiasis was commoner among those 15-45 years (96.2%), than those <15 years (3.2%) and >45 years (0.6%). Moreover, the unmarried bear a greater burden of the infection (52%) than the married (48%) and this difference was statistically significant (p═0.001). Conclusion: Candida albicans infection is the commonest cause of pathologic vaginal discharge in Aminu Kano Teaching Hospital, Kano, Nigeria and it is commoner in the unmarried and in those within the reproductive age group.

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  HYPONATRAEMIA IN PATIENTS WITH END-STAGE RENAL DISEASE IN MAIDUGURI  

I UMMATE, BM MUBI, I GEZAWA

Correspondence to: DR IBRAHIM UMMATE Department of Medicine, University of Maiduguri Teaching Hospital, PMB 1414, Maiduguri E-mail; This email address is being protected from spambots. You need JavaScript enabled to view it.

Objectives: To determine the prevalence of hyponatraemia in patients with End Stage Renal Disease (ESRD) in our centre. Methods: One hundred patients with CKD comprising 68 males and 32 females were enrolled into the study. Patients' demographic data were compared with controls. Serum samples were taken for electrolytes, urea and creatinine, calcium, phosphate, total protein albumin and virology. Ultrasonography was also done on all the patients. Results; 100 patients aged between 15 and 74yrs (mean±SD of 35.29±14.17) and 57 controls aged 15 to 75yrs (mean±SD of 39.9±13.58) were studied. There was no significant difference in the ages of the patients and controls (p=0.79). The cases comprised 68 males and 32 females. Mean±SD age of males was 41±13.27yrs and that of the females was 36.06±13.64yrs. Two (2%) of the study population had severe hyponatraemia with serum Na less than 120mmol/l, while 47 (47%) had mild to moderate hyponatraemia with serum Na between 120-134mmol/l; in contrast to 49 (49%) who had normal serum Na between 135-145mm0l/l, and 2 (2%) who had hypernatraema with serum Na greater than 145mmol/l. There is no age or sex predilection in the distribution of hyponatraemia in the study group (p=0.854 and p=0.436, respectively). We conclude that there is no statistical difference in the serum Na concentration among patients with CKD regardless of the aetiology and degree of renal dysfunction (p=0.076 and p=0.722). Hyponatremia is common among ESRD patients undergoing haemodialysis and this problem should always be looked for because majority of patients with this condition are asymptomatic.

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  ATTITUDES OF POSTGRADUATE RESIDENT DOCTORS TOWARD PSYCHIATRY  

WAKIL MA* SALAWU FK** ABDULMALIK JO*** AHIDJO A**** BEIDA O*****

Correspondence to: DR. MUSA ABBA WAKIL Department of Mental Health, College of Medical Sciences, University of Maiduguri, Nigeria. e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .

Background: A significant proportion of patients presenting to general practitioners and non-psychiatric specialists have been shown to suffer from underlying or co-morbid psychiatric conditions. The detection rate and appropriate treatment or referral of such psychiatric conditions varies widely depending on the attitude, expertise and level of familiarity of the physician with psychiatry. A negative attitude towards psychiatry often precludes efforts to understand and manage such disorders thus worsening the hidden burden of mental illness. Objectives: To evaluate the attitudes of postgraduate resident doctors toward psychiatry. Method: A cross-sectional survey on a convenience sample of 100 postgraduate resident doctors from the University of Maiduguri Teaching Hospital was conducted using a modified version of the self-rated Kumar 12-item questionnaire and a brief socio-demographic questionnaire. Results: The subjects comprised of 74.3% males and 25.7% females, with age ranges of 25-45 years and mean of 32.6+ 4.1. The majority (95.7%) opined that psychiatry was a valid and important specialty, while 80% of the respondents had encountered psychiatric cases in their respective specialties. Furthermore, 91.8% of the respondents appreciated that psychosocial factors may influence the presentation, course and outcome of physical illnesses. Conclusion: Postgraduate resident doctors in Maiduguri displayed a high level of awareness about psychiatry and its relevance. This positive approach needs to be built upon via the strengthening of reciprocal consultation-liaison services, in order to enhance holistic care for patients.

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January - June 2008
Volume 5 | Issue 1

This journal has been online since Saturday, April 05, 2013

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  SENSITIVITY PATTERN OF BACTERIAL ISOLATES FROM PURULENT CONJUNCTIVITIS IN NGURU, NORTHEAST, NIGERIA

GB Gadzama, B H Askira, B Z Ali

Correspondence to: Dr B H Askira, Department of Ophthalmology, UMTH, PMB 1414, Maiduguri. E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Background: Bacterial conjunctivitis is a common condition encountered in practice Objective: To ascertain the commonest cause of Bacterial conjunctivitis in this environment and its sensitivity pattern.
Design: This was cross sectional hospital- based study, carried out from January to December 2006 on all patients that attended the ophthalmology clinic with purulent conjunctivitis. The affected eyes were swabbed for the microscopy culture and sensitivity after obtaining their consent. Results: There were 129 specimens sent for microscopy, culture and sensitivity. , 82(63.6%) yielded no bacterial growth while 47(36.4%) yielded significant growth. The most frequent Bacteria isolated were Staphylococcus aureus (46.9%) and Klebsiella spp (17.0%). Other bacteria seen include E coli (6.4%), Haemophilus influenzae (8.5%), Neisseria gonorrhoeae (10.6%) and Proteus spp (10.6%). The antimicrobial agent that showed the highest sensitivity among all the isolates was ciprofloxacin while chloramphenicol showed the least sensitivity. Conclusion: Staphylococcus aureus was found to be the commonest cause of bacterial conjunctivitis and ciprofloxacin the most sensitive antimicrobial agent to all bacterial isolates.

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  CERVICAL INCOMPETENCE AND PREGNANCY OUTCOME IN JOS UNIVERSITY TEACHING HOSPITAL: A FOUR-YEAR REVIEW

MUHAMMAD Z, IBRAHIM SA
Correspondence to: Dr S A Ibrahim, Department of Obstetrics and Gynaecology, Aminu Kano Teaching Hospital, Kano. PMB 3452, Kano Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Background: Cervical incompetence continues to pose a challenge to the obstetrican as a cause of repeated midtrimester abortion.Several observational studies into the efficacy of cervical Cerclage have claimed high rates of successful pregnancy outcome in women with poor obstetric history attributed to cervical incompetence. Objectives: The objectives of the study are to determine the prevalence of cervical incompetence in Jos University Teaching Hospital (JUTH), the complications of the treatment modalities, and the pregnancy outcome. Study design, setting and subject: This is a 4 years retrospective review of 144 pregnancies in (135) patients with cervical incompetence in the Jos University Teaching Hospital. Patients diagnosed to have cervical incompetence and who had cervical Cerclage, antenatal care and delivery in the Jos University Teaching Hospital, Jos, formed the study population. Main outcome measures: Prevalence, post insertion complications and Pregnancy outcome, among patients with cervical incompetence who had cervical cerclage in Jos University Teaching Hospital, Jos Plateau state. Results: A total of one hundred and fourty four pregnancies were reviewed retrospectively in one hundred and thirty five patients with cervical incompetence over a four-year period. The diagnosis of cervical incompetence was established by history 63% of pregnancies, and by ultra-sonography in 35% of pregnancies. The McDonald technique of repair was employed in 90% of the cases. The incidence of cervical incompetence over the period of review was 1 in every 69 deliveries. The most common post insertion complications were premature rupture of membranes (20.8%) Vulvovaginitis (16%) and urinary tract infection (10.5%). The term births accounted for 62.5% and preterm births for 22.9%, with overall fetal salvage of 85.4%.

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  PREVALENCE OF THROMBOCYTOPAENIA IN HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTION IN ZARIA  

BABADOKO AA, AMINU SM, SULEIMAN AM

Correspondence to: BABADOKO, A. A., Department of Haematology and Blood Transfusion, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. E mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Background: Thrombocytopaenia is relatively common during the course of HIV infection and it may serve as the first evidence of infection. It has been associated with clinical or immunological severity of the disease. Multiple interacting factors may contribute to this haematological manifestation of HIV infection. Aim: To determine the prevalence of thrombocytopaenia and its relationship to CD4+ T lymphocyte count in antiretroviral naïve HIV-1
infected patients. Methodology: Four hundred consecutive HIV-1 infected patients undergoing pre treatment investigations for staging were recruited over a one year period, at the HIV subspecialty clinic of Ahmadu Bello University Teaching Hospital, Zaria. All the patients were confirmed HIV-1 infected, repeatedly reactive by ELISA. Platelet count was determined by standard manual method and CD4+ T cell enumeration by Dynal® (Oslo Norway) manual method. Results: Of the 400 patients studied, the prevalence of thrombocytopaenia was 6.25% with a male to female ratio of 1:1.7. There is a significant positive correlation between platelet count and CD4 + T lymphocyte count r 0.086, P 0.043 (p < 0.05), however this association is weak by clinical/immunological staging. Conclusion: Thrombocytopaenia is not an uncommon finding in HIV infected patients in our setting and often occurs in the severely immunocompromised individual. Platelet count cannot be used as a substitute to determine the severity of immunosuppression.

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  PREVALENCE OF DYSMENORRHOEA IN MAIDUGURI, NORTH EASTERN NIGERIA  

MB KAWUWA, A A KULLIMA, B M AUDU, A G MAIRIGA, HA USMAN, BG BAKO
Correspondence to: DR A A KULLIMA Department of obstetrics and Gynaecology, Federal Medical Centre Nguru PMB 02 Nguru. Yobe state E mail : This email address is being protected from spambots. You need JavaScript enabled to view it.

Background: Dysmenorrhoea is the most common gynaecologic complaint among adolescents and young females. It is often regarded by many as normal, seeking medical attention only when it is unbearable. Objective: To determine the prevalence, risk factors and effects of dysmenorrhoea among women in Maiduguri. Methods: This is a cross sectional descriptive study among female students in six tertiary institutions in Maiduguri, Borno state. Three hundred structured questionnaires were administered to ascertain the epidemiology, associated risk factors and possible effect of dysmenorrhoea. Results: About 63% currently had pain during menses and 69.7% had experienced primary dysmenorrhoea in the past. One third each of such pain were moderate (35%) to require medication and severe (31.7%) as to restrict routine activities, in 8.3% the menstrual pain was so severe to warrant admission in the hospital. There was significant association between current dysmenorrhoea and previous primary dysmenorrhoea, positive family history of dysmenorrhoea, past history of D& C and other gynaecological problems, while smoking was not shown to have any statistically significant relationship. There was an inverse relationship between previous pregnancies and current episode of dysmenorrhoea Conclusion: Dysmenorrhoea is prevalent among women, yet many do not seek medical attention unless it became unbearable..

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NMA BORNO STATE CHAPTER

NIGERIA MEDICAL ASSOCIATION
BORNO STATE CHAPTER OFFICIALS

Prof. Bukar Bakki -Chairman
Dr. Umar Loskurima - Vice Chairman

Dr. Kaka Mahdi Gazali Secretary

Dr. Nasir Garba Zango Assistant Secretary

Dr. Ali Maina Zubiru - Treasurer

Dr. Muhammad Abba Fugu - Financial Secretary

Dr. Abba M. Ibrahim - Social/Welfare Officer

Dr. Mukhtar Abubakar - Publicity Secretary

Prof. Modu Gofama Mustapha - Editor-in-chief

Dr. Ali Mohammed Ramat - Ex-officio I

Dr. Abdulhakeem M Ngulde - Ex-officio II

MDCAN UMTH

MEDICAL AND DENTAL CONSULTANTS’
ASSOCIATION OF NIGERIA, UMTH CHAPTER OFFICIALS

Dr. Babagana Usman Chairman
Dr. Abubakar Farouk - Vice Chairman

Dr. Mohammed A.S. Abdullahi Secretary

Dr. Abubakar Farate- Assistant Secretary

Dr. Aisha Abba Mohammed- Treasurer

Dr. Kefas M. Mbaya- Publicity Secretary

Prof. Modu Gofama Mustapha - Editor-in-chief

Dr. Hassan M. Dogo - Ex-officio I

Prof. Adamu Sadiq Abubakar - Ex-officio II

. . .